ABSTRACT
We compared the efficacy and side effects of postoperative continous infusions versus intermittent intravenous on-demand morphine, with or without the addition of clonixin. Eighty five helthy patients, aged 18 to 65 years, scheduled for elective cholecystectomy were prospectively randomized: group 1 (n=22) received morphine 2,5 mg iv on-demand; group 2 (n=22) received a clonixin 400 mg/day iv infusion; group 3 (n=19) a morphine 0,4 mg/kg/day iv infusion; and group 4 (n=22) received a clonixin 400 mg/day plus a morphine 0,4 mg/kg/day iv infusion. Groups 2, 3 and 4 also received, on-demand 2,5 mg iv bolus doses of morphine. A blind observer recorder analogue and descriptive pain scores, respiratory rates and side effects for 72 hours postoperatively. Groups with morphine infusions had less overall pain scores for the first day when compared with intermitent dosing (p<0.05); these groups also had less pain during the night (p=0.0016) and required less aditional morphine (p<0.0001). Side effects were similar and no cases of heavy sedation or respiratory depression were observed. We conclude that a morphine 0.4 mg/kg/day infusion is a safe and effective alternative to on demand dosing in helathy patients after elective cholecystectomy, achieving better analgesia without increasing side-effects. Clonixin 400 mg/day seems to add no significant benefits
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Pain, Postoperative/drug therapy , Cholecystectomy , Morphine/administration & dosage , Infusions, Intravenous , Clonixin/administration & dosage , Meperidine , Pain MeasurementABSTRACT
Estudiamos en forma retrospectiva la morbimortalidad periperatoria en 80 pacientes valvulópatas sometidos a cirugía no cardíaca entre 1988 y 1989. Once pacientes (14%) presentaron una o más complicaciones, de los cuales fallecieron cuatro (5%). Dos pacientes con falla de bomba y uno por embolia mesentérica presentaron una necrosis mesentérica posoperatoria y fallecieron. El mayor deterioro de la capacidad funcional (CF) (p = 0,052), la cirugía de urgencia (p = 0,002) y la cirugía abdominal alta (p = 0,016) se asociaron a una mayor morbilidad. No hubo diferencias de morbilidad entre los pacientes con o sin cirugía valvular previa. A mayor puntaje en las clasificaciones de ASA (p = 0,018), Goldman (p < 0,001) o Detsky (p < 0,001), se asoció una mayor morbilidad. Las clasificaciones descritas son útiles en la detección de pacientes de mayor riesgo; su uso es recomendada para optimizar las condiciones perioperatorias en los pacientes de alto riesgo y disminuir así la morbimortalidad